Sphinx
Kai-Fu Lee's system was the first to recognise continuous, large-vocabulary speech from any speaker, with no tuning to the voice.
Why it matters
Three requirements considered incompatible were met together, and that combination is what made recognition usable.
Before Sphinx a system either required pauses between words, or worked with a small vocabulary, or had to be trained on a particular speaker. Lee combined hidden Markov models with context-dependent triphones and parameter sharing between them, which let the model train on limited data. Business Week named it the most important innovation of 1988. The open-source CMU Sphinx line exists to this day.