Logic Theorist
The program by Newell, Shaw and Simon proved theorems from Principia Mathematica by searching plausible derivations rather than all of them.
Why it matters
The first program to do work considered exclusively human, and to do it by heuristic search rather than enumeration.
Logic Theorist proved 38 of the first 52 theorems in chapter two of Principia Mathematica, and found a shorter proof of theorem 2.85 than Whitehead and Russell's. The Journal of Symbolic Logic rejected a paper that listed the program as a co-author. To build it, Newell and Shaw created the IPL list-processing language.